Products for Research Use Only
RegisterLogin

CDK4/6-IN-10

CAT: 0804-HY-115993Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-115993Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
CDK4/6-IN-10 is a potent, selective and orally active CDK4 and CDK6 inhibitor with IC50s of 22 nM and 10 nM, respectively. CDK4/6-IN-10 shows antitumor activity. CDK4/6-IN-10 has the potential for the research of Multiple myeloma (MM) [1].
CAS Number
2688098-11-3
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk4-6-in-10.html
Solubility
10 mM in DMSO
Smiles
CN1C=C(C2=NC(NC3=NC=C(CN4CCNCC4)C=C3)=NC=C2F)C5=CC=CN=C51
Molecular Formula
C22H23FN8
Molecular Weight
418.47
References & Citations
[1]Yuan K, et al. Discovery of novel and orally bioavailable CDK 4/6 inhibitors with high kinome selectivity, low toxicity and long-acting stability for the treatment of multiple myeloma. Eur J Med Chem. 2022; 228:114024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK4; CDK6

Related Products

CatalogName
HY-168444CDK4/6-IN-23
HY-162529CDK4/6-IN-19
HY-114339-01CDK4/6-IN-2
HY-172146CDK4/6-IN-24
HY-143258CDK4/6-IN-8
HY-142076-01CDK4/6-IN-15
HY-153088-01CDK4/6-IN-16
HY-115992-01CDK4/6-IN-9
HY-179151CDK4/6-IN-26
HY-143257CDK4/6-IN-7

Alternative Products

CatalogName
GTR19184467-01CDK4/6-IN-10
sc-166373Cdk4 (B-10)
MBS5785595CDK4/6-IN-6
sc-166373 FITCCdk4 (B-10) FITC
sc-166373 PECdk4 (B-10) PE
sc-166373 HRPCdk4 (B-10) HRP
sc-166373 ACCdk4 (B-10) AC
T204550-01CDK4/6-IN-23
T72928-01CDK4/6-IN-15
T60328-01CDK4/6-IN-12

Popular Products