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COX-2-IN-10

CAT: 0804-HY-115976Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-115976Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
COX-2-IN-10 is a potent COX-2 inhibitor. COX-2-IN-10 inhibits the production of PGE2 in concentration dependent manner (IC50=2.54 μM) . COX-2-IN-10 inhibits the expression of iNOS and COX-2 on mRNA and protein level . COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β[1].
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-in-10.html
Solubility
10 mM in DMSO
Smiles
CC(C)(N1C=C(C(C2=CC(F)=CC=C2)=N1)C3=CC=NC(NCCCNS(=O)(C4=CC5=C(C=C4)C=CC=C5)=O)=C3)C
Molecular Formula
C31H32FN5O2S
Molecular Weight
557.68
References & Citations
[1]Karim I. M, et al. Design, synthesis, in vitro determination and molecular docking studies of 4- (1- (tert-butyl) -3-phenyl-1H-pyrazol-4-yl) pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.7 macrophage cells. Medicinal Chemistry Research, 2021, 30: 1925-1942.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2

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