COX-2-IN-32

COX-2-IN-32

• CAS Number: 2725863-08-9
• UNSPSC Description: COX-2-IN-32 (Compound 2f) is an iNOS and COX-2 inhibitor. COX-2-IN-32 decreases the expression of NF-κB. COX-2-IN-32 has anti-inflammatory activity by inhibits NO production in LPS-induced RAW264.7 macrophages (IC50: 11.2 μM)[1].
• Target Antigen: COX; NF-κB; NO Synthase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;NF-κB
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/cox-2-in-32.html
• Solubility: 10 mM in DMSO
• Smiles: COC(C=C1)=CC=C1OC(C=C2)=CC=C2/C=C/C(C3=CC(OC)=C(C(OC)=C3)OC)=O
• Molecular Weight: 420.45
• References & Citations: [1]Emam SH, et al. Design and synthesis of methoxyphenyl- and coumarin-based chalcone derivatives as anti-inflammatory agents by inhibition of NO production and down-regulation of NF-κB in LPS-induced RAW264.7 macrophage cells. Bioorg Chem. 2021 Feb;107:104630.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported