COX-2-IN-55

CAT: 0931-T211247-01Size: 10 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0931-T211247-01Size:10 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

CAS Number

2649115-80-8

Target

Calcium Channel, VEGFR, Caspase

Related Pathways

Metabolism, Tyrosine Kinase/Adaptors, Membrane transporter/Ion channel, Apoptosis, Angiogenesis, Proteases/Proteasome

Bioactivity

COX-2-IN-55 (compound 1) is an orally active Celecoxib analogue with broad-spectrum anticancer properties and relatively weak COX-2 inhibition. It specifically inhibits SERCA2, leading to increased caspase-3 cleavage and DR5 levels, which activates GRP78 and suppresses the progression of triple-negative breast cancer (TNBC) . Additionally, COX-2-IN-55 downregulates the angiogenesis markers VEGF-α and IL-8, thereby inhibiting microvessel formation.

Smiles

O=S(=O)(NC=1C=CC=C(N)C1)C2=CC=C(C=C2)N3N=C(C=C3C=4C=C(C=CC4C)C)C(F)(F)F

Molecular Formula

C24H21F3N4O2S

Molecular Weight

486.51

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Related Products

Catalog	Name
T10032-01	COX-2-IN-2
T89933-01	COX-2-IN-46
T89018-01	COX-2-IN-44
T86083-01	COX-2-IN-40
T60457-01	COX-2-IN-11
T61264-01	COX-2-IN-19
T61714-01	COX-2-IN-13
T209486-01	COX-2-IN-42
T209034-01	COX-2-IN-37
T205175-01	COX-2-IN-52

Alternative Products

Catalog	Name
HY-171992-01	COX-2-IN-55
311865-01	Cox-2
GTR19206710-01	COX-2-IN-2
BA5932-10	COX-2-IN-6
HY-175637	COX-2-IN-57
HY-174159	COX-2-IN-54
HY-153762-01	COX-2-IN-32
HY-145988	COX-2-IN-11
HY-146198	COX-2-IN-19
HY-U00275	COX-2-IN-1

COX-2-IN-55

Related Products

Alternative Products

Popular Products