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Ac-IETD-AFC

CAT: 0804-HY-P1169-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P1169-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ac-IETD-AFC is a fluorogenic substrate of caspase-8, caspase-3, caspase-10, and granzyme B[1].
CAS Number
211990-57-7
UNSPSC
12171500
Target
Caspase
Type
Dye Reagents
Related Pathways
Apoptosis
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ac-ietd-afc.html
Purity
99.28
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic)
Smiles
FC(F)(C(C(C(O1)=C2)=CC=C2NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)[C@@H](C)CC)=O)=O)=O)=O)=CC1=O)F
Molecular Formula
C31H38F3N5O12
Molecular Weight
729.65
References & Citations
[1][1]Kazimierz Weglarczyk, et al. Caspase-8 activation precedes alterations of mitochondrial membrane potential during monocyte apoptosis induced by phagocytosis and killing of Staphylococcus aureus. Infect Immun. 2004 May;72 (5) :2590-7. |[2]Przemysław Reszka, et al. Synthesis, enzymatic evaluation, and docking studies of fluorogenic caspase 8 tetrapeptide substrates. ChemMedChem. 2010 Jan;5 (1) :103-17.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Dye Reagents
Clinical Information
No Development Reported

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