P-gp/BCRP-IN-1

P-gp/BCRP-IN-1

• CAS Number: 2764596-06-5
• UNSPSC Description: P-gp/BCRP-IN-1 (compound 19) is a potential, relatively safe, orally active and efficient efflux transporter (P-gp and BCRP) inhibitor. P-gp/BCRP-IN-1 exerts resistance reversal by inhibiting the efflux function of P-gp and BCRP. P-gp/BCRP-IN-1 can overcome the resistance and improve the oral bioavailability of PTX (Paclitaxel)[1].
• Target Antigen: BCRP
• Type: Reference compound
• Related Pathways: Membrane Transporter/Ion Channel
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/p-gp-bcrp-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=NN(C(C2=CC=CC=C21)=O)C3=CC=C(C=C3)Cl)NC4=CC=C(C=C4)CCN5CCOCC5
• Molecular Weight: 488.97
• References & Citations: [1]Shi W, Zhang P, Zou F, et al. Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel. Eur J Med Chem. 2022;233:114231.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported