Trap-101 (hydrochloride)

• Description:

  Trap-101 hydrochloride is a potent, selective and competitive antagonist of NOP receptors over classical opioid receptors. Trap-101 stimulates GTPγ35S binding to CHOhNOP membranes with pKi values of 8.65, 6.60, 6.14 and [1].

• UNSPSC:

  12352005

• Hazard Statement:

  H301

• Target:

  Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/trap-101-hydrochloride.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1N(CC)C2=CC=CC=C2N1C3=C(CO)CN(CC4CCCCCCC4)CC3.[H]Cl

• Molecular Formula:

  C24H36ClN3O2

• Molecular Weight:

  434.01

• Precautions:

  P264-P270-P330-P405-P501

• References & Citations:

  [1]Matteo Marti, et al. The novel nociceptin/orphanin FQ receptor antagonist Trap-101 alleviates experimental parkinsonism through inhibition of the nigro-thalamic pathway: positive interaction with L-DOPA. J Neurochem. 2008 Dec;107 (6) :1683-96.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NOP Receptor/ORL1

• CAS Number:

  [1216621-00-9]