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AVN-101 (hydrochloride)

CAT: 0804-HY-117046A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117046A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AVN-101 hydrochloride is a potent, brain-penetrant and orally active 5-HT7 receptor antagonist (Ki of 153 pM), with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors (Ki values of 2.04 nM, 1.56 nM, and 1.17 nM, respectively) . AVN-101 hydrochloride also exhibits a rather high affinity toward histamine H1 (Ki of 0.58 nM) and adrenergic α2A, α2B, and α2C (Ki= 0.41-3.6 nM) receptors. AVN-101 hydrochloride can be studied in such diseases as general anxiety disorders, depression, schizophrenia, Alzheimer’s disease, and multiple sclerosis[1].
CAS Number
1061354-48-0
Product Name Alternative
PPT
UNSPSC
12352005
Target
5-HT Receptor; Adrenergic Receptor; Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/avn-101-hydrochloride.html
Purity
99.59
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
CC1=CC2=C(C=C1)N(C3=C2CN(CC3)C)CCC4=CC=CC=C4.[H]Cl
Molecular Formula
C21H25ClN2
Molecular Weight
340.89
References & Citations
[1]Alexandre V Ivachtchenko, et al. AVN-101: A Multi-Target Drug Candidate for the Treatment of CNS Disorders. J Alzheimers Dis. 2016 May 25;53 (2) :583-620.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-HT2 Receptor;5-HT6 Receptor;5-HT7 Receptor; H1 Receptor; mLAG-3; MUC2; MUC3; α adrenergic receptor; α-1 microglobulin

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