MAL3-101

• Description :

  MAL3-101 is a potent HSP70 allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC) [1].

• UNSPSC :

  12352005

• Target :

  HSP

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/mal3-101.html

• Purity :

  98.22

• Solubility :

  DMSO : 50 mg/mL (ultrasonic)

• Smiles :

  CC(N(C(NC1C2=CC=C(C3=CC=CC=C3)C=C2)=O)CCCCCC(N(CCCCCC)C(C(NCCCC)=O)C4=CC=C(C(C(OC)=O)=C4)OCC(OC)=O)=O)=C1C(OCC5=CC=CC=C5)=O

• Molecular Formula :

  C54H66N4O10

• Molecular Weight :

  931.12

• References & Citations :

  [1]Prince T, et al. Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer. Oncotarget. 2018 Aug 24;9 (66) :32702-32717.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HSP70

• CAS Number :

  [831217-40-4]