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MAL3-101

CAT: 0804-HY-124805-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-124805-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MAL3-101 is a potent HSP70 allosteric inhibitor. MAL3-101 inhibits HSP70 ATPase activity by blocking Hsp40 co-chaperone interaction. MAL3-101 can be used for researching muscle invasive bladder cancer (MIBC) [1].
CAS Number
[831217-40-4]
UNSPSC
12352005
Target
HSP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mal3-101.html
Purity
98.22
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(N(C(NC1C2=CC=C(C3=CC=CC=C3)C=C2)=O)CCCCCC(N(CCCCCC)C(C(NCCCC)=O)C4=CC=C(C(C(OC)=O)=C4)OCC(OC)=O)=O)=C1C(OCC5=CC=CC=C5)=O
Molecular Formula
C54H66N4O10
Molecular Weight
931.12
References & Citations
[1]Prince T, et al. Dual targeting of HSP70 does not induce the heat shock response and synergistically reduces cell viability in muscle invasive bladder cancer. Oncotarget. 2018 Aug 24;9 (66) :32702-32717.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HSP70

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