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UWA-101 (hydrochloride)

CAT: 0804-HY-117512-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117512-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UWA-101 hydrochloride is a selective and non-cytotoxic DAT/SERT inhibitor, with EC50 values of 3.6 µM and 2.3 µM for inhibiting DAT and SERT, respectively. UWA-101 hydrochloride can alleviate the side effects of dopaminergic agents (such as L-DOPA), such as motor disorders, and lacks psychotropic activity. UWA-101 hydrochloride can be used for research on neurodegenerative diseases such as Parkinson's disease[1][2].
CAS Number
1431520-52-3
UNSPSC
12352005
Target
Dopamine Transporter; Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/uwa-101-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CNC(C1CC1)CC2=CC=C3OCOC3=C2.Cl
Molecular Formula
C13H18ClNO2
Molecular Weight
255.74
References & Citations
[1]Johnston TH, et al. A novel MDMA analogue, UWA-101, that lacks psychoactivity and cytotoxicity, enhances L-DOPA benefit in parkinsonian primates. FASEB J. 2012 May;26 (5) :2154-63.|[2]Huot P, et al. Monoamine reuptake inhibitors in Parkinson's disease. Parkinsons Dis. 2015;2015:609428.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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