TRAP-6

• Description :

  TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4[1].

• Product Name Alternative :

  PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6

• UNSPSC :

  12352209

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Protease Activated Receptor (PAR)

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/TRAP-6.html

• Purity :

  99.98

• Solubility :

  H2O : 25 mg/mL (ultrasonic)

• Smiles :

  O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(O)=O)CC(N)=O)=O)=O)=O)[C@@H](NC([C@@H](N)CO)=O)CC1=CC=CC=C1

• Molecular Formula :

  C34H56N10O9

• Molecular Weight :

  748.87

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Kahn ML, et, al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103 (6) :879-87.|[2]Kinlough-Rathbone RL, et, al. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood. 1993 Jul 1;82 (1) :103-6.|[3]Chintala MS, et, al. Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats. Eur J Pharmacol. 1998 May 22;349 (2-3) :237-43.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  PAR1

• CAS Number :

  [141136-83-6]