TRAP-6

• Description:

  TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4[1].

• Product Name Alternative:

  PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6

• UNSPSC:

  12352209

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Protease Activated Receptor (PAR)

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/TRAP-6.html

• Purity:

  99.98

• Solubility:

  H2O : 25 mg/mL (ultrasonic)

• Smiles:

  O=C (N[C@@H] (CC (C) C) C (N[C@@H] (CC (C) C) C (N[C@@H] (CCCNC (N) =N) C (N[C@H] (C (O) =O) CC (N) =O) =O) =O) =O) [C@@H] (NC ([C@@H] (N) CO) =O) CC1=CC=CC=C1

• Molecular Formula:

  C34H56N10O9

• Molecular Weight:

  748.87

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Kahn ML, et, al. Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin. J Clin Invest. 1999 Mar;103 (6) :879-87.|[2]Kinlough-Rathbone RL, et, al. Rabbit and rat platelets do not respond to thrombin receptor peptides that activate human platelets. Blood. 1993 Jul 1;82 (1) :103-6.|[3]Chintala MS, et, al. Disparate effects of thrombin receptor activating peptide on platelets and peripheral vasculature in rats. Eur J Pharmacol. 1998 May 22;349 (2-3) :237-43.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  PAR1

• CAS Number:

  141136-83-6