TRAP-1

• Description :

  TRAP-1 (XJZ-06-462) is a selective p53Y220C transcriptional activator. TRAP-1 can engage p53Y220C and BRD4 in a ternary complex, which potently activates mutant p53 and triggers robust p53 target gene transcription. TRAP-1 rapidly upregulates p21 and other p53 target genes in pancreatic cell lines with p53Y220C. TRAP-1 exhibits higher antiproliferative activity in BxPC-3 (p53Y220C) cells than in A549 cells (p53WT), with IC50 values of 0.531 μM and 3.94 μM, respectively. TRAP-1 can be used for the study of p53Y220C-bearing cancer.

• Product Name Alternative :

  XJZ-06-462

• UNSPSC :

  12352005

• Target :

  Apoptosis; MDM-2/p53

• Type :

  Reference compound

• Related Pathways :

  Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/trap-1.html

• Purity :

  99.69

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(N1CCN(CC2CCN(C(CN3CCC(NC4=CC=CC5=C4C=C(C#CCNC6=CC=C(P(C)(C)=O)C=C6)N5CC(F)(F)F)CC3)=O)CC2)CC1)C[C@H]7C8=NN=C(C)N8C9=C(C(C)=C(C)S9)C(C%10=CC=C(Cl)C=C%10)=N7

• Molecular Formula :

  C57H66ClF3N11O3PS

• Molecular Weight :

  1108.69

• References & Citations :

  [1]Xijun Zhu, et al. Activating p53Y220C with a Mutant-Specific Small Molecule. bioRxiv. 2024 Oct 28:2024.10.23.619961.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported