TRAP-1

• UNSPSC Description:

  TRAP-1 (XJZ-06-462) is ap53 transcriptional activator that effectively activates mutant p53 and triggers the transcription of p53 target genes. TRAP-1 rapidly upregulates p21 and other p53 target genes in pancreatic cell lines with p53Y220C. TRAP-1 inhibits cell proliferation, with IC50 values of 3.94 and 0.531 μM in BxPC-3 and A549 cells, respectively. TRAP-1 regulates autophagy in lung cancer cells and offers protective effects against oxidative stress and cell apoptosis[1][2][3].

• Target Antigen:

  Apoptosis; Autophagy; MDM-2/p53

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/trap-1.html

• Smiles:

  O=C(N1CCN(CC2CCN(C(CN3CCC(NC4=CC=CC5=C4C=C(C#CCNC6=CC=C(P(C)(C)=O)C=C6)N5CC(F)(F)F)CC3)=O)CC2)CC1)C[C@H]7C8=NN=C(C)N8C9=C(C(C)=C(C)S9)C(C%10=CC=C(Cl)C=C%10)=N7

• Molecular Weight:

  1108.69

• References & Citations:

  [1]Xijun Zhu, et al. Activating p53Y220C with a Mutant-Specific Small Molecule. bioRxiv. 2024 Oct 28:2024.10.23.619961.|[2]N Montesano Gesualdi, et al. Tumor necrosis factor-associated protein 1 (TRAP-1) protects cells from oxidative stress and apoptosis. Stress. 2007 Nov;10(4):342-50.|[3]Inês A Barbosa, et al. TRAP1 regulates autophagy in lung cancer cells. Eur J Clin Invest. 2018 Apr;48(4).

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported