TC-E 5008

• Description :

  TC-E 5008 is a potent mutant IDH1 inhibitor with Ki values of 190 nM and 120 nM for R132H and R132C IDH1 mutants, respectively. TC-E 5008 exhibits very weak activity against WT-IDH1 with a Ki value of 12.3 μM. TC-E 5008 has anti-proliferative activity on multiple ER positive breast cancer cell lines[1][2].

• UNSPSC :

  12352005

• Target :

  Isocitrate Dehydrogenase (IDH)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tc-e-5008.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ON1C(CC2=CC=CC=C2)=CC(C)=CC1=O

• Molecular Formula :

  C13H13NO2

• Molecular Weight :

  215.25

• References & Citations :

  [1]Baisong Zheng, et al. Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett. 2013 Jun 13;4 (6) :542-546.|[2]Vasanth S. Murali, et al. Cancer drug discovery as a low rank tensor completion problem. bioRxiv, March 9, 2021.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  IDH1

• CAS Number :

  [50405-58-8]