TC-E 5008

• UNSPSC Description:

  TC-E 5008 is a potent mutant IDH1 inhibitor with Ki values of 190 nM and 120 nM for R132H and R132C IDH1 mutants, respectively. TC-E 5008 exhibits very weak activity against WT-IDH1 with a Ki value of 12.3 μM. TC-E 5008 has anti-proliferative activity on multiple ER positive breast cancer cell lines[1][2].

• Target Antigen:

  Isocitrate Dehydrogenase (IDH)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/tc-e-5008.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ON1C(CC2=CC=CC=C2)=CC(C)=CC1=O

• Molecular Weight:

  215.25

• References & Citations:

  [1]Baisong Zheng, et al. Crystallographic Investigation and Selective Inhibition of Mutant Isocitrate Dehydrogenase. ACS Med Chem Lett. 2013 Jun 13;4(6):542-546.|[2]Vasanth S. Murali, et al. Cancer drug discovery as a low rank tensor completion problem. bioRxiv, March 9, 2021.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  50405-58-8