TC-2153

• Description :

  TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling[1].

• UNSPSC :

  12352005

• Target :

  5-HT Receptor; Monoamine Oxidase

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/tc-2153.html

• Concentration :

  10mM

• Purity :

  98.73

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  NC1=C2SSSSSC2=CC(C(F)(F)F)=C1.[H]Cl

• Molecular Formula :

  C7H5ClF3NS5

• Molecular Weight :

  355.89

• References & Citations :

  [1]Walters JM, et al. Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity. Epilepsia. 2022 May;63 (5) :1211-1224.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT1 Receptor;5-HT2 Receptor; MAO-A; mLAG-3; α-1 microglobulin

• CAS Number :

  [1381769-23-8]