TC-2153

• UNSPSC Description:

  TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling[1].

• Target Antigen:

  5-HT Receptor; Monoamine Oxidase

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/tc-2153.html

• Purity:

  98.73

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  NC1=C2SSSSSC2=CC(C(F)(F)F)=C1.[H]Cl

• Molecular Weight:

  355.89

• References & Citations:

  [1]Walters JM, et al. Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity. Epilepsia. 2022 May;63(5):1211-1224.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  1381769-23-8