TC-F2

CAT: 0804-HY-103462-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-103462-01Size:5 mg

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Description

TC-F2 is a reversible non-covalent binding inhibitor of fatty acid amide hydrolase (FAAH) with an IC50 of 28 nM. FAAH is involved in many human diseases, particularly cancer, pain and inflammation as well as neurological, metabolic and cardiovascular disorders[1].

CAS Number

1304778-15-1

UNSPSC

12352005

Target

FAAH

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Cancer; Inflammation/Immunology; Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/tc-f2.html

Purity

99.35

Solubility

DMSO : 250 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1N([C@]2([H])CN(C3=NC=CC(C4=CC5=CC=CC=C5O4)=N3)CCC2)C6=CC=CC=C6N1CC

Molecular Formula

C26H25N5O2

Molecular Weight

439.51

References & Citations

[1]Florian M Dato, et al. Characterization of fatty acid amide hydrolase activity by a fluorescence-based assay. Anal Biochem. 2018 Apr 1;546:50-57.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

1-{(3s)-1-[4-(1-Benzofuran-2-Yl)pyrimidin-2-Yl]piperidin-3-Yl}-3-Ethyl-1,3-Dihydro-2h-Benzimidazol-2-One

CAS Number	1304778-15-1
PubChem CID	25198728
IUPAC Name	1-[(3S)-1-[4-(1-benzofuran-2-yl)pyrimidin-2-yl]piperidin-3-yl]-3-ethylbenzimidazol-2-one
Molecular Formula	C26H25N5O2
Molecular Weight	439.5
XLogP	4.4
Topological Polar Surface Area	65.7
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Heavy Atom Count	33
Formal Charge	0
Complexity	706

SMILES

CCN1C2=CC=CC=C2N(C1=O)[C@H]3CCCN(C3)C4=NC=CC(=N4)C5=CC6=CC=CC=C6O5

InChI

InChI=1S/C26H25N5O2/c1-2-30-21-10-4-5-11-22(21)31(26(30)32)19-9-7-15-29(17-19)25-27-14-13-20(28-25)24-16-18-8-3-6-12-23(18)33-24/h3-6,8,10-14,16,19H,2,7,9,15,17H2,1H3/t19-/m0/s1

InChIKey

NXTBLPPTZRPJCA-IBGZPJMESA-N

Chemical Structure

2D Structure

CAS: 1304778-15-1

CID: 25198728

Formula: C26H25N5O2

MW: 439.5

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	439.5
XLogP3	4.4
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	4
Exact Mass	439.20082506
Monoisotopic Mass	439.20082506
Topological Polar Surface Area	65.7 Å²
Heavy Atom Count	33
Formal Charge	0
Complexity	706
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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