TC-1698

• Description :

  TC-1698 is a selective α7 nicotinic acetylcholine receptors agonist with EC50 value of 0.16 μM and 0.46 μM for monkey α7 nicotinic receptor and human α7 nicotinic receptor, respectively. TC-1698 improves memory and has neuroprotective effects. TC-1698 can be used for Alzheimer's disease research[1].

• CAS Number :

  [700834-58-8]

• UNSPSC :

  12352005

• Target :

  NAChR

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/tc-1698.html

• Solubility :

  10 mM in DMSO

• Smiles :

  N1(CC2)C(C3=CC=CN=C3)CCC2CC1

• Molecular Formula :

  C13H18N2

• Molecular Weight :

  202.30

• References & Citations :

  [1]Mazurov AA, et al. Discovery and development of α7 nicotinic acetylcholine receptor modulators. J Med Chem. 2011 Dec 8;54 (23) :7943-61.|[2]Marrero MB, et al. The neuroprotective effect of 2- (3-pyridyl) -1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J Pharmacol Exp Ther. 2004 Apr;309 (1) :16-27.|[3]Papke RL, et al. Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2005 Nov 7;524 (1-3) :11-8.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported