TC-E 5001

• Description :

  TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively[1][2].

• UNSPSC :

  12352005

• Target :

  PARP; Wnt

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tc-e-5001.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1=NN=C(SCC2=NC(C3=CC=C(OC)C=C3)=NO2)N1C4=CC=C(OC)C=C4

• Molecular Formula :

  C20H19N5O3S

• Molecular Weight :

  409.46

• References & Citations :

  [1]Shultz MD, et, al. [1,2,4]triazol-3-ylsulfanylmethyl) -3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem. 2012 Feb 9;55 (3) :1127-36.|[2]Lien VT, et, al. Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation. RSC Advances. 2019 Jour; 9 (63) : 37092-37100.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TNKS1/PARP5A; TNKS2/PARP5B

• CAS Number :

  [865565-29-3]