TC-E 5001

CAT: 0804-HY-108516Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-108516Size:1 Each
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Description
TC-E 5001 is an inhibitor of Wnt pathway that inhibits tankyrase 1/2 (TNKS1/2) via novel adenosine pocket binding, with Kds of 79 nM and 28 nM, respectively. TC-E 5001 also inhibits Axin2 and STF, with IC50s of 0.709 μM and 0.215 μM, respectively[1][2].
CAS Number
[865565-29-3]
UNSPSC
12352005
Target
PARP; Wnt
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tc-e-5001.html
Solubility
10 mM in DMSO
Smiles
CC1=NN=C(SCC2=NC(C3=CC=C(OC)C=C3)=NO2)N1C4=CC=C(OC)C=C4
Molecular Formula
C20H19N5O3S
Molecular Weight
409.46
References & Citations
[1]Shultz MD, et, al. [1,2,4]triazol-3-ylsulfanylmethyl) -3-phenyl-[1,2,4]oxadiazoles: antagonists of the Wnt pathway that inhibit tankyrases 1 and 2 via novel adenosine pocket binding. J Med Chem. 2012 Feb 9;55 (3) :1127-36.|[2]Lien VT, et, al. Towards dual inhibitors of the MET kinase and WNT signaling pathway; design, synthesis and biological evaluation. RSC Advances. 2019 Jour; 9 (63) : 37092-37100.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TNKS1/PARP5A; TNKS2/PARP5B

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