TC-E 5005

• Description :

  TC-E 5005 is a potent and selective PDE10A inhibitor with IC50 values of 7.28, 239, 779, 919, 3,100, and 3,700 nM for PDE10A, 2A, 11A, 5A, 7B and 3A, respectively. TC-E 5005 inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate[1].

• UNSPSC :

  12352005

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/tc-e-5005.html

• Solubility :

  10 mM in DMSO

• Smiles :

  COC1=CC=C2C(N3C(C(C)=N2)=C(C)N=C3CCC)=N1

• Molecular Formula :

  C15H18N4O

• Molecular Weight :

  270.33

• References & Citations :

  [1]Hennenberg M, et al. Inhibition of Adrenergic and Non-Adrenergic Smooth Muscle Contraction in the Human Prostate by the Phosphodiesterase 10-Selective Inhibitor TC-E 5005. Prostate. 2016 Nov;76 (15) :1364-74.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PDE10; PDE11; PDE2; PDE3; PDE5; PDE7

• CAS Number :

  [959705-64-7]