TC-6683

• Description :

  TC-6683 (AZD1446) is a selective α4β2 nicotinic acetylcholine receptor (nAChR) agonist. TC-6683 does not show significant therapeutic effects in the animal model of DYT1 dystonia.TC-6683 can be used for the research of neurological disease, such as cognitive disorder[1][2].

• Product Name Alternative :

  AZD1446

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  NAChR

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research :

  Neurological Disease

• Smiles :

  O=C(N1CC2CNCC2C1)C3=CC=C(Cl)O3

• Molecular Formula :

  C11H13ClN2O2

• Molecular Weight :

  240.69

• Precautions :

  P264-P270-P330-P501

• References & Citations :

  [1]Mazurov AA, et al. Discovery of 3- (5-chloro-2-furoyl) -3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders. J Med Chem. 2012 Nov 8;55 (21) :9181-94.|[2]Zimmerman CN, et al. Evaluation of AZD1446 as a Therapeutic in DYT1 Dystonia. Front Syst Neurosci. 2017 Jun 13;11:43.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [1025007-04-8]