TC-SP 14

CAT: 0804-HY-108492Size: 1 EachDry Ice: NoHazardous: No

CAT#:0804-HY-108492Size:1 Each

Selected

PRICE

AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

1 / 1

Description

TC-SP 14 (compound 14) is an orally active and potent S1P1 agonist (EC50 = 0.042 μM) with minimal activity at S1P3 (EC50 = 3.47 μM) . TC-SP 14 significantly reduces blood lymphocyte counts and attenuates a delayed type hypersensitivity (DTH) response to antigen challenge[1].

CAS Number

[1257093-40-5]

UNSPSC

12352005

Target

LPL Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/tc-sp-14.html

Solubility

10 mM in DMSO

Smiles

O=C(C1CN(CC2=CC=C(C3=NC4=CC(CC5=CC=CC=C5F)=CC=C4S3)C(F)=C2)C1)O

Molecular Formula

C25H20F2N2O2S

Molecular Weight

450.50

References & Citations

[1]Lanman BA, et al. Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1) . ACS Med Chem Lett. 2010 Nov 9;2 (2) :102-6.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

S1PR1; S1PR3

Related Products

Catalog	Name
HY-164864-01	DU-14 (PTP1B/TC-PTP PROTAC)
HY-163545	Tc-Me2P
HY-103462-01	TC-F2
HY-124591-01	TC-2153
HY-107668A	TC-1698
HY-18159	TC-6683
HY-172367	Tc-BQ0413
HY-W979493-01	TC-2216
HY-103330	TC-C 14G
HY-103266-01	TC-A 2317 (hydrochloride)

Alternative Products

Catalog	Name
MBS5802295	TC-SP 14
MBS3611862-01	TC-I2000
MBS3617315-01	TC-067533
A04D04-TC	Streptavidin-TC
MBS3840024-01	TC-DAPK6
T33776-01	Ochratoxin TC
T210105-01	Tc-Me2P
T68154-01	TC-2216
T70818-01	TC-2153
4300/1	TC 14012

TC-SP 14

Related Products

Alternative Products

Popular Products