TC-SP 14

• UNSPSC Description:

  TC-SP 14 (compound 14) is an orally active and potent S1P1 agonist (EC50 = 0.042 μM) with minimal activity at S1P3 (EC50 = 3.47 μM). TC-SP 14 significantly reduces blood lymphocyte counts and attenuates a delayed type hypersensitivity (DTH) response to antigen challenge[1].

• Target Antigen:

  LPL Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/tc-sp-14.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1CN(CC2=CC=C(C3=NC4=CC(CC5=CC=CC=C5F)=CC=C4S3)C(F)=C2)C1)O

• Molecular Weight:

  450.50

• References & Citations:

  [1]Lanman BA, et al. Discovery of a Potent, S1P3-Sparing Benzothiazole Agonist of Sphingosine-1-Phosphate Receptor 1 (S1P1). ACS Med Chem Lett. 2010 Nov 9;2(2):102-6.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1257093-40-5