DU-14 (PTP1B/TC-PTP PROTAC)

DU-14 (PTP1B/TC-PTP PROTAC)

• CAS Number: 3053413-58-1
• UNSPSC Description: DU-14 (PTP1B/TC-PTP PROTAC) is a potent and selective PTP1B and TC-PTP dual PROTAC degrader. DU-14 (PTP1B/TC-PTP PROTAC) has the IC50 for PTP1B and TC-PTP phosphatase activity of 24.2 nM and 30.1 nM, respectively. DU-14 (PTP1B/TC-PTP PROTAC) enhances IFN-γ signaling, promotes T cell activation, and has anti-tumor activity. (Pink: PTP1B/TC-PTP inhibitor (HY-171027); Black: Linker (HY-W340290); Blue: E3 ligand (HY-112078))[1].
• Target Antigen: PROTACs; STAT
• Type: Reference compound
• Related Pathways: JAK/STAT Signaling;PROTAC;Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/du-14-ptp1b-tc-ptp-protac.html
• Smiles: O=P(O)(O)C(F)(F)C(C=C1)=CC=C1C[C@H](NC([C@@H](NC(CC2=CC(OC)=C(C=C2)O)=O)CC3=CC=CC=C3)=O)C(N[C@@H](CCCCNC(C4=CC(Br)=C(C=C4)C)=O)C(NCC5=CC=CC(CC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C8=C(N=CS8)C)C=C7)C)=O)=O)=O)=C5)=O)=O
• Molecular Weight: 1505.46
• References & Citations: [1]Dong J, et al. Small Molecule Degraders of Protein Tyrosine Phosphatase 1B and T-Cell Protein Tyrosine Phosphatase for Cancer Immunotherapy. Angew Chem Int Ed Engl. 2023 May 22;62(22):e202303818.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported