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3-Hydroxy Midostaurin-d5

CAT: 0804-HY-108263SSize: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108263SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
3-Hydroxy Midostaurin-d5 is a deuterium labeled 3-Hydroxy Midostaurin. 3-Hydroxy Midostaurin is a metabolite of PKC412, which effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively[1].
Product Name Alternative
CGP52421-D5
UNSPSC
12352005
Target
FLT3; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
OC1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6OC)N(C(C(C([2H])=C9[2H])=C(C([2H])=C9[2H])[2H])=O)C)C)=O
Molecular Formula
C35H25D5N4O5
Molecular Weight
591.67
References & Citations
[1]Levis M, et al. Plasma inhibitory activity (PIA) : a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108 (10) :3477-83.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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