3-Hydroxy Midostaurin-13C6

CAT: 0804-HY-W751180Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-W751180Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
3-Hydroxy Midostaurin-13C6 (CGP52421-13C6) is the 13C-labeled 3-Hydroxy Midostaurin (HY-108263) . 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412[1].
Product Name Alternative
CGP52421-13C6
UNSPSC
12352005
Target
FLT3; Isotope-Labeled Compounds
Related Pathways
Others; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(N([C@@H]1C[C@H]2O[C@@](C)([C@@H]1OC)N3C4=C(C5=C3C6=C(C7=C(N26)C=CC=C7)C8=C5C(NC8=O)O)C=CC=C4)C)[13C]9=[13CH][13CH]=[13CH][13CH]=[13CH]9
Molecular Formula
C29 13C6H30N4O5
Molecular Weight
592.59
References & Citations
[1]Levis M, et al. Plasma inhibitory activity (PIA) : a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108 (10) :3477-83.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-W751179Midostaurin-13C6
HY-1082633-Hydroxy Midostaurin
HY-108263A-01(S) -3-Hydroxy Midostaurin
HY-108263S3-Hydroxy Midostaurin-d5
HY-108263B-01(R) -3-Hydroxy Midostaurin
HY-W751181O-Desmethyl midostaurin-13C6
HY-10230-01Midostaurin
HY-15550S14'-Hydroxy diclofenac-13C6
HY-W7771886-Hydroxy Chlorzoxazone-13C6
HY-10230SMidostaurin-d5

Alternative Products

CatalogName
TRC-H939987-10MG3-Hydroxy Midostaurin-13C6
TRC-H939985-2.5MG3-Hydroxy Midostaurin
MBS57718053-Hydroxy Midostaurin-D5
MF-0008403-01(R) -3-Hydroxy Midostaurin
MF-0027342-01(S) -3-Hydroxy Midostaurin
MBS5767540(S)-3-Hydroxy Midostaurin
MBS5767420(R)-3-Hydroxy Midostaurin
MF-0056625-013 Hydroxy Midostaurin Epimer 1-d5
MF-0056626-013 Hydroxy Midostaurin Epimer 2-d5
TRC-H829403-50MG3-Hydroxy Benzopyrene-13C6

Popular Products