3-Hydroxy Midostaurin

• Target:

  FLT

• Related Pathways:

  Tyrosine Kinase/Adaptors|||Angiogenesis

• Bioactivity:

  3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of approximately 132 nM in culture medium and 9.8 ?M in plasma. Although less selective, it shows greater cytotoxicity compared to PKC412[1].

• Smiles:

  CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4C(O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1

• Molecular Formula:

  C35H30N4O5

• Molecular Weight:

  586.648

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  179237-49-1