3-Hydroxy Midostaurin

CAT: 0931-MF-0025524-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0025524-01Size:100 mg
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CAS Number
179237-49-1
Target
FLT
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis
Bioactivity
3-Hydroxy Midostaurin (CGP 52421), a PKC412 metabolite, inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50 values of approximately 132 nM in culture medium and 9.8 ?M in plasma. Although less selective, it shows greater cytotoxicity compared to PKC412[1].
Smiles
CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4C(O)NC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)c1ccccc1
Molecular Formula
C35H30N4O5
Molecular Weight
586.648
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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