(R) -3-Hydroxy Midostaurin

• Description :

  (R) -3-Hydroxy Midostaurin ((R) -CGP52421) is a potent kinases inhibitor. (R) -3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R) -3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML) [1].

• CAS Number :

  [155848-20-7]

• Product Name Alternative :

  (R) -CGP52421

• UNSPSC :

  12352005

• Target :

  Drug Metabolite; FLT3

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/r-3-hydroxy-midostaurin.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@H]1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6OC)N(C(C9=CC=CC=C9)=O)C)C)=O

• Molecular Formula :

  C35H30N4O5

• Molecular Weight :

  586.64

• References & Citations :

  [1]Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57 (38) :5576-5590.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported