(R)-3-Hydroxy Midostaurin

(R)-3-Hydroxy Midostaurin

• CAS Number: 155848-20-7
• UNSPSC Description: (R)-3-Hydroxy Midostaurin ((R)-CGP52421) is a potent kinases inhibitor. (R)-3-Hydroxy Midostaurin is a major metabolite of midostaurin (PKC412; HY-10230) undergoing by the hepatic CYP3A4 enzyme. (R)-3-Hydroxy Midostaurin has the potential for acute myeloid leukemia (AML)[1].
• Target Antigen: Drug Metabolite; FLT3
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/r-3-hydroxy-midostaurin.html
• Solubility: 10 mM in DMSO
• Smiles: O[C@H]1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6OC)N(C(C9=CC=CC=C9)=O)C)C)=O
• Molecular Weight: 586.64
• References & Citations: [1]Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported