Midostaurin-d5

• Description :

  Midostaurin-d5 (PKC412-d5) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

• Product Name Alternative :

  PKC412-d5; CGP 41251-d5

• UNSPSC :

  12352005

• Target :

  Akt; c-Kit; Isotope-Labeled Compounds; PKA; PKC; Syk

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Epigenetics; Others; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Purity :

  98.0

• Solubility :

  DMSO : 15 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2

• Molecular Formula :

  C35H25D5N4O4

• Molecular Weight :

  575.67

• References & Citations :

  [1]Fabbro D, et al. Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent. Pharmacol Ther. 1999 May-Jun;82 (2-3) :293-301.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported