Midostaurin-d5

Midostaurin-d5

• UNSPSC Description: Midostaurin-d5 is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].
• Target Antigen: Akt; c-Kit; Isotope-Labeled Compounds; PKA; PKC; Syk
• Type: Isotope-Labeled Compounds
• Related Pathways: Epigenetics;Others;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt;TGF-beta/Smad
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Purity: 98.0
• Solubility: DMSO : 15 mg/mL (ultrasonic;warming)
• Smiles: O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2
• Molecular Weight: 575.67
• References & Citations: [1]Fabbro D, et al. Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent. Pharmacol Ther. 1999 May-Jun;82(2-3):293-301.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported