Midostaurin-d5

• Description:

  Midostaurin-d5 (PKC412-d5) is a deuterium labeled Midostaurin. Midostaurin is a multi-targeted protein kinase inhibitor which inhibits PKCα/β/γ, Syk, Flk-1, Akt, PKA, c-Kit, c-Fgr, c-Src, FLT3, PDFRβ and VEGFR1/2 with IC50s ranging from 22-500 nM[1].

• Product Name Alternative:

  PKC412-d5; CGP 41251-d5

• UNSPSC:

  12352005

• Target:

  Akt; c-Kit; Isotope-Labeled Compounds; PKA; PKC; Syk

• Type:

  Isotope-Labeled Compounds

• Related Pathways:

  Epigenetics; Others; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Purity:

  98.0

• Solubility:

  DMSO : 15 mg/mL (ultrasonic; warming)

• Smiles:

  O=C(C1=C([2H])C([2H])=C([2H])C([2H])=C1[2H])N(C)[C@H]2[C@@H](OC)[C@@]3(C)N(C4=C5C=CC=C4)C6=C5C7=C(C(NC7)=O)C8=C6N(C9=CC=CC=C98)[C@@](O3)([H])C2

• Molecular Formula:

  C35H25D5N4O4

• Molecular Weight:

  575.67

• References & Citations:

  [1]Fabbro D, et al. Inhibitors of protein kinases: CGP 41251, a protein kinase inhibitor with potential as an anticancer agent. Pharmacol Ther. 1999 May-Jun;82 (2-3) :293-301.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported