(S)-3-Hydroxy Midostaurin

• UNSPSC Description:

  (S)-3-Hydroxy Midostaurin ((S)-CGP52421) is a potent kinases inhibitor with IC50 values of [1].

• Target Antigen:

  Drug Metabolite; FLT3

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-3-hydroxy-midostaurin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H]1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(C)[C@@H]([C@@H](C[C@](O6)([H])N7C5=C2C8=C7C=CC=C8)N(C(C9=CC=CC=C9)=O)C)OC)=O

• Molecular Weight:

  586.64

• References & Citations:

  [1]Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57(38):5576-5590.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  945260-14-0