(S) -3-Hydroxy Midostaurin

CAT: 0804-HY-108263A-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108263A-01Size:1 mg
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Description
(S) -3-Hydroxy Midostaurin ((S) -CGP52421) is a potent kinases inhibitor with IC50 values of [1].
CAS Number
[945260-14-0]
Product Name Alternative
(S) -CGP52421
UNSPSC
12352005
Target
Drug Metabolite; FLT3
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/s-3-hydroxy-midostaurin.html
Solubility
10 mM in DMSO
Smiles
O[C@@H]1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(C)[C@@H]([C@@H](C[C@](O6)([H])N7C5=C2C8=C7C=CC=C8)N(C(C9=CC=CC=C9)=O)C)OC)=O
Molecular Formula
C35H30N4O5
Molecular Weight
586.64
References & Citations
[1]Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57 (38) :5576-5590.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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