(S) -3-Hydroxy Midostaurin

• Description:

  (S) -3-Hydroxy Midostaurin ((S) -CGP52421) is a potent kinases inhibitor with IC50 values of [1].

• Product Name Alternative:

  (S) -CGP52421

• UNSPSC:

  12352005

• Target:

  Drug Metabolite; FLT3

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/s-3-hydroxy-midostaurin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@@H]1NC(C2=C1C(C3=C4C=CC=C3)=C5N4[C@]6(C)[C@@H]([C@@H](C[C@](O6)([H])N7C5=C2C8=C7C=CC=C8)N(C(C9=CC=CC=C9)=O)C)OC)=O

• Molecular Formula:

  C35H30N4O5

• Molecular Weight:

  586.64

• References & Citations:

  [1]Manley PW, et al. Comparison of the Kinase Profile of Midostaurin (Rydapt) with That of Its PredominantMetabolites and the Potential Relevance of Some Newly Identified Targets to Leukemia Therapy. Biochemistry. 2018 Sep 25;57 (38) :5576-5590.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [945260-14-0]