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O-Desmethyl Midostaurin-d5

CAT: 0804-HY-129491SSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129491SSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
O-Desmethyl Midostaurin-d5 is a deuterium labeled O-Desmethyl PKC412. O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin via cytochrome P450 liver enzyme metabolism[1].
CAS Number
2699608-28-9
Product Name Alternative
CGP62221-d5; O-Desmethyl PKC412-d5
UNSPSC
12352005
Target
Drug Metabolite; Isotope-Labeled Compounds
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(C(C3=C4C=CC=C3)=C5N4[C@]6(O[C@@H](N7C5=C2C8=C7C=CC=C8)C[C@H]([C@H]6O)N(C(C(C([2H])=C9[2H])=C(C([2H])=C9[2H])[2H])=O)C)C)CN1
Molecular Formula
C34H23D5N4O4
Molecular Weight
561.64
References & Citations
[1]Levis M, et al. Plasma inhibitory activity (PIA) : a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors. Blood. 2006 Nov 15;108 (10) :3477-83.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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TMIH-0404-01O-Desmethyl Midostaurin-d5
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