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O-Desmethyl Midostaurin

CAT: 0804-HY-129491-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-129491-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.
CAS Number
740816-86-8
Product Name Alternative
CGP62221; O-Desmethyl PKC412
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/o-desmethyl-pkc412.html
Purity
97.08
Solubility
10 mM in DMSO
Smiles
O=C(N([C@@H]1C[C@]([H])(N2C3=C4C=CC=C3)O[C@](C)(N5C6=C2C4=C(C(NC7)=O)C7=C6C8=C5C=CC=C8)[C@@H]1O)C)C9=CC=CC=C9
Molecular Formula
C34H28N4O4
Molecular Weight
556.61
References & Citations
[1]Levis M, et al. Plasma inhibitory activity (PIA) : a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108 (10) :3477-83.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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