O-Desmethyl Midostaurin

• Product Name Alternative:

  CGP62221; O-Desmethyl PKC412

• UNSPSC Description:

  O-Desmethyl Midostaurin (CGP62221; O-Desmethyl PKC412) is the active metabolite of Midostaurin (HY-10230) via cytochrome P450 liver enzyme metabolism. O-Desmethyl Midostaurin can be used as an indicator for Midostaurin metabolism in vivo[1]. Midostaurin is a multi-targeted protein kinase inhibitor with IC50 ranging from 22-500 nM.

• Target Antigen:

  PKC

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;TGF-beta/Smad

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/o-desmethyl-pkc412.html

• Purity:

  95.48

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N([C@@H]1C[C@]([H])(N2C3=C4C=CC=C3)O[C@](C)(N5C6=C2C4=C(C(NC7)=O)C7=C6C8=C5C=CC=C8)[C@@H]1O)C)C9=CC=CC=C9

• Molecular Weight:

  556.61

• References & Citations:

  [1]Levis M, et al. Plasma inhibitory activity (PIA): a pharmacodynamic assay reveals insights into the basis for cytotoxic response to FLT3 inhibitors.Blood. 2006 Nov 15;108(10):3477-83.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  740816-86-8