AP 24149

• UNSPSC Description:

  AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1].

• Target Antigen:

  Bcr-Abl; Src

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ap-24149.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=P(C)(C)C(C=C1)=CC=C1NC2=C3N=CN(/C=C/C4=C(C)C=CC=C4C)C3=NC=N2

• Molecular Weight:

  417.44

• References & Citations:

  [1]Zhou T, et al. Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template. Chem Biol Drug Des. 2010 Jan;75(1):18-28.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  926922-29-4