AP 24149

CAT: 0804-HY-10363Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-10363Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1].

CAS Number

926922-29-4

UNSPSC

12352005

Target

Bcr-Abl; Src

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ap-24149.html

Solubility

10 mM in DMSO

Smiles

O=P(C)(C)C(C=C1)=CC=C1NC2=C3N=CN(/C=C/C4=C(C)C=CC=C4C)C3=NC=N2

Molecular Formula

C23H24N5OP

Molecular Weight

417.44

References & Citations

[1]Zhou T, et al. Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template. Chem Biol Drug Des. 2010 Jan;75 (1) :18-28.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Abl

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AP 24149

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