AP-C6

CAT: 0804-HY-153542Size: 1 EachDry Ice: NoHazardous: No

CAT#:0804-HY-153542Size:1 Each

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Description

AP-C6 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP) -dependent protein kinase II (cGKII) with a pIC50 of 6.5. AP-C6 concentration-dependently inhibits human cGKII activity in vitro. AP-C6 potentiate cAMP signaling by PDE inhibition[1].

CAS Number

[2234276-60-7]

UNSPSC

12352005

Target

PKG

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/ap-c6.html

Solubility

10 mM in DMSO

Smiles

OCCNC1=NC=CC(C2=CC=C(N3C=NC=C3)C=C2)=N1

Molecular Formula

C15H15N5O

Molecular Weight

281.31

References & Citations

[1]Marcel J C Bijvelds, et al. Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J Biol Chem. 2018 May 25;293 (21) :8173-8181.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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AP-C6

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