AP-C6

• UNSPSC Description:

  AP-C6 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 6.5. AP-C6 concentration-dependently inhibits human cGKII activity in vitro. AP-C6 potentiate cAMP signaling by PDE inhibition[1].

• Target Antigen:

  PKG

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/ap-c6.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OCCNC1=NC=CC(C2=CC=C(N3C=NC=C3)C=C2)=N1

• Molecular Weight:

  281.31

• References & Citations:

  [1]Marcel J C Bijvelds, et al. Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J Biol Chem. 2018 May 25;293(21):8173-8181.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2234276-60-7