AP-C6

AP-C6

• CAS Number: 2234276-60-7
• UNSPSC Description: AP-C6 is a potent inhibitor of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 6.5. AP-C6 concentration-dependently inhibits human cGKII activity in vitro. AP-C6 potentiate cAMP signaling by PDE inhibition[1].
• Target Antigen: PKG
• Type: Reference compound
• Related Pathways: Stem Cell/Wnt
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/ap-c6.html
• Solubility: 10 mM in DMSO
• Smiles: OCCNC1=NC=CC(C2=CC=C(N3C=NC=C3)C=C2)=N1
• Molecular Weight: 281.31
• References & Citations: [1]Marcel J C Bijvelds, et al. Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors. J Biol Chem. 2018 May 25;293(21):8173-8181.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported