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P-fin4

CAT: 0804-HY-P3355Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-P3355Size:1 Each
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Description
P-fin4 is a peptide inhibitor of STEP Phosphatase-GluA2 AMPA receptor interaction with a Ki of 0.4 μM. p-fin4 restores the memory deficits and displays anxiolytic and antidepressant effects in a scopolamine-treated rat model. p-fin4 is a promising lead compound for novel cognitive enhancers and/or behavioral modulators[1].
CAS Number
2883747-74-6
UNSPSC
12352209
Target
IGluR
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/p-fin4.html
Solubility
10 mM in DMSO
Smiles
N[C@@](CCC(O)=O)(C(NCC(N[C@@](Cc1ccc(O)cc1)(C(N[C@@](CC(N)=O)(C(N[C@@](C(C)C)(C(N[C@H](C(N[C@@](CCC(O)=O)(C(O)=O)[H])=O)CC2=CC=C(C=C2)OP(O)(O)=O)=O)[H])=O)[H])=O)[H])=O)=O)[H]
Molecular Formula
C39H53N8O18P
Molecular Weight
952.85
References & Citations
[1]Szedlacsek HS, et al. Designed Peptide Inhibitors of STEP Phosphatase-GluA2 AMPA Receptor Interaction Enhance the Cognitive Performance in Rats. J Med Chem. 2022;65 (1) :217-233.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
AMPA Receptor

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