APL-1081

• Description :

  APL-1081 (Mal-Exo-EVC-MMAE) is part of an antibody-conjugated active molecule (ADC) . APL-1081 is conjugated with an ADC linker (peptide Mal-Exo-EEVC) and a potent tubulin polymerization inhibitor, MMAE (HY-15162) [1].

• Product Name Alternative :

  Mal-Exo-EVC-MMAE

• UNSPSC :

  12352203

• Target :

  Drug-Linker Conjugates for ADC; Microtubule/Tubulin

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage; Cytoskeleton

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/apl-1081.html

• Purity :

  99.79

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OC(C3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)C(NCCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)OC)=O

• Molecular Formula :

  C75H115N13O19

• Molecular Weight :

  1502.79

• References & Citations :

  [1]Watanabe T, et al. Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody–Drug Conjugates[J]. Journal of Medicinal Chemistry, 2024.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• CAS Number :

  [2921735-80-8]