APL-1082

• Description :

  APL-1082 (exo-EVC-Exatecan) is a drug-Linker conjugate that can be used for ADC synthesis. Its structure contains Exatecan (HY-13631) (ADC payload) and linker (HY-175929) [1].

• UNSPSC :

  12352005

• Target :

  Drug-Linker Conjugates for ADC

• Related Pathways :

  Antibody-drug Conjugate/ADC Related

• Field of Research :

  Cancer

• Smiles :

  O=C(C=CC1=O)N1CCCCCNC(C(C2=CC=C(C=C2)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)OC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O

• Molecular Formula :

  C60H70FN11O16

• Molecular Weight :

  1220.26

• References & Citations :

  [1]Watanabe T, et al. Biological Evaluation of Cleavable Linkers in Exatecan-Based Antibody-Drug Conjugates: A Comparative Study of DXd and Exo-Linker Platforms. ACS Omega. 2025 Aug 19;10 (34) :38696-38702.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2921735-93-3]