APL-1082

CAT: 0804-HY-175888Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175888Size:1 Each
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Description
APL-1082 (exo-EVC-Exatecan) is a drug-Linker conjugate that can be used for ADC synthesis. Its structure contains Exatecan (HY-13631) (ADC payload) and linker (HY-175929) [1].
CAS Number
[2921735-93-3]
UNSPSC
12352005
Target
Drug-Linker Conjugates for ADC
Related Pathways
Antibody-drug Conjugate/ADC Related
Field of Research
Cancer
Smiles
O=C(C=CC1=O)N1CCCCCNC(C(C2=CC=C(C=C2)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)OC(N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84)=O)=O
Molecular Formula
C60H70FN11O16
Molecular Weight
1220.26
References & Citations
[1]Watanabe T, et al. Biological Evaluation of Cleavable Linkers in Exatecan-Based Antibody-Drug Conjugates: A Comparative Study of DXd and Exo-Linker Platforms. ACS Omega. 2025 Aug 19;10 (34) :38696-38702.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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