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APL-1091

CAT: 0804-HY-169323Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169323Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
APL-1091 (Mal-Exo-EEVC-MMAE) is part of a Drug-linker conjugate for ADC. APL-1091 contains a Mal-Exo-EEVC linker and MMAE (HY-15162) (Microtubule inhibitor). APL-1091 can be used for ADC synthesis[1].
CAS Number
2921735-87-5
Product Name Alternative
Mal-Exo-EEVC-MMAE
UNSPSC
12352211
Target
Drug-Linker Conjugates for ADC
Type
Reference compound
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apl-1091.html
Smiles
O[C@@H](C1=CC=CC=C1)[C@@H](C)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OC(C3=CC=C(C=C3)NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC([C@H](CCC(O)=O)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)=O)C(NCCCCCN4C(C=CC4=O)=O)=O)=O)=O)=O)=O)OC)=O
Molecular Formula
C80H122N14O22
Molecular Weight
1631.91
References & Citations
[1]Watanabe T, et al. Exo-Cleavable Linkers: Enhanced Stability and Therapeutic Efficacy in Antibody-Drug Conjugates. J Med Chem. 2024 Oct 24;67 (20) :18124-18138.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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