ABBV-167

• UNSPSC Description:

  ABBV-167 is a phosphate proagent of the BCL-2 inhibitor venetoclax.

• Target Antigen:

  Bcl-2 Family

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/abbv-167.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC1(CCC(CN2CCN(CC2)C3=CC(OC4=CN(C5=NC=CC5=C4)COP(O)(O)=O)=C(C=C3)C(NS(=O)(C6=CC([N+]([O-])=O)=C(C=C6)NCC7CCOCC7)=O)=O)=C(C1)C8=CC=C(C=C8)Cl)C

• Molecular Weight:

  978.45

• References & Citations:

  [1]Salem AH, et al. Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers. Mol Cancer Ther. 2021 Jun;20(6):999-1008.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  1351456-78-4