ABBV-467

• UNSPSC Description:

  ABBV-467 is a selective MCL-1 inhibitor (Ki: apoptosis. ABBV-467 induces cancer cell death and inhibits tumor growth in models of hematological malignancies, such as multiple myeloma[1].

• Target Antigen:

  Apoptosis; Bcl-2 Family

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/abbv-467.html

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  O=C(O)[C@@H](CC1=CC2=CC=C1OCC3=NC(C4=CC=C(OC[C@H]5OCCOC5)C=C4)=NC=C3)OC6=NC=NC7=C6C(C8=C(C)C(Cl)=C(O[C@@H](CO2)CN9CCN(C)CC9)C(Cl)=C8C)=C(C%10=CC=C(F)C=C%10)S7

• Molecular Weight:

  1037.98

• References & Citations:

  [1]Yuda J, et al. Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients. Commun Med (Lond). 2023 Oct 25;3(1):154.

• Shipping Conditions:

  Blue Ice

• Clinical Information:

  Phase 1

• CAS Number:

  2287186-66-5