ABBV-318

• Description :

  ABBV-318 is a potent Nav1.7/ Nav1.8 blocker, with IC50s of 2.8 μM and 3.8 μM for hNav1.7 and hNav1.8, respectively. ABBV-318 can be used for the research of pain[1].

• UNSPSC :

  12352005

• Target :

  Sodium Channel

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/abbv-318.html

• Concentration :

  10mM

• Purity :

  98.72

• Solubility :

  DMSO : 166.67 mg/mL (ultrasonic)

• Smiles :

  O=C(N1C[C@H](F)CC1)C2=NC3=CC=C(OC4=NC=C(C(F)(F)F)C=C4)C=C3C=C2

• Molecular Formula :

  C20H15F4N3O2

• Molecular Weight :

  405.35

• References & Citations :

  [1]Patel MV, et, al. Discovery of (R) - (3-fluoropyrrolidin-1-yl) (6- ((5- (trifluoromethyl) pyridin-2-yl) oxy) quinolin-2-yl) methanone (ABBV-318) and analogs as small molecule Na v 1.7/ Nav1.8 blockers for the treatment of pain. Bioorg Med Chem. 2022 Jun 1;63:116743.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Nav1.7; Nav1.8

• CAS Number :

  [1802848-94-7]