ABBV-154

• Description :

  ABBV-154 is an anti-TNF antibody-drug conjugate (ADC) . ABBV-154 is composed of the humanized antibody Adalimumab (HY-P9908) conjugated with a glucocorticoid receptor modulator (HY-137883) . ABBV-154 can be used in studies of rheumatoid arthritis, Crohn's disease and polymyalgia rheumatica[1].

• UNSPSC :

  12352203

• Target :

  Antibody-Drug Conjugates (ADCs) ; Glucocorticoid Receptor; TNF Receptor

• Type :

  Reference compound

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Apoptosis; Immunology/Inflammation; Vitamin D Related/Nuclear Receptor

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/abbv-154.html

• Smiles :

  [ABBV-154]

• References & Citations :

  [1]Hobson AD, et al. Discovery of ABBV-154, an anti-TNF Glucocorticoid Receptor Modulator Immunology Antibody-Drug Conjugate (iADC) . J Med Chem. 2023 Sep 14;66 (17) :12544-12558.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  Phase 2