ABBV-712

• Description :

  ABBV-712 is a selective and orally active inhibitor of Tyrosine kinase 2 (TYK2) . ABBV-712 has EC50 values of 0.01, 0.19, and 0.17 μM for TYK2 JH2, TYK2 cells and human whole blood, respectively. ABBV-712 has anti-inflammatory activity and can be used in the research of autoimmune diseases[1].

• UNSPSC :

  12352005

• Target :

  JAK

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/abbv-712.html

• Purity :

  99.94

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  CC(NC1=CC2=C(C=N1)N(C=C2C3=NC([C@]4(COCC4)OC)=CC(COC)=C3)C5COC5)=O

• Molecular Formula :

  C24H28N4O5

• Molecular Weight :

  452.50

• References & Citations :

  [1]Eric Breinlinger, et al. Targeting the Tyrosine Kinase 2 (TYK2) Pseudokinase Domain: Discovery of the Selective TYK2 Inhibitor ABBV-712. J Med Chem. 2023 Oct 26;66 (20) :14335-14356.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2368945-27-9]