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ABBV-744

CAT: 0804-HY-112090-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-112090-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ABBV-744 is a first-in-class, orally active and selective inhibitor of the BDII domain of BET family proteins with IC50 values ranging from 4 to 18 nM for BRD2, BRD3, BRD4 and BRDT. ABBV-744 is primarily metabolized by CYP3A4 with agent-like properties enable the investigation of its antitumor efficacy and tolerability[1].
CAS Number
[2138861-99-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Epigenetic Reader Domain; HIV
Type
Reference compound
Related Pathways
Anti-infection; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ABBV-744.html
Purity
99.95
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(O)(C)C1=CC(C(C2=C3NC(C(NCC)=O)=C2)=CN(C)C3=O)=C(OC4=C(C)C=C(F)C=C4C)C=C1
Molecular Formula
C28H30FN3O4
Molecular Weight
491.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Faivre EJ, et al. Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer. Nature. 2020;578 (7794) :306-310.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
BRD2; BRD3; BRD4; BRDT

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Alternative Products

CatalogName
TRC-A215290-50MGABBV 744
MBS132850ABBV-744
A16831-10ABBV-744 10mg
A16831-200ABBV-744 200mg
A16831-2ABBV-744 2mg
A16831-50ABBV-744 50mg
A16831-5ABBV-744 5mg
A16831-25ABBV-744 25mg
A16831-1ABBV-744 1mg
A16831-100ABBV-744 100mg

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