PROTAC SMARCA2 degrader-24

• UNSPSC Description:

  PROTAC SMARCA2 degrader-24 (Compound 34) is a PROTAC degrader for SMARCA2 with a DC50 SMARCA4 with a DC50 > 10 μM in HeLa[1].

• Target Antigen:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-smarca2-degrader-24.html

• Smiles:

  CC1=C(SC=N1)C2=CC=C(C=C2)[C@@H](NC([C@@H]3C[C@H](CN3C(C(C(C)C)C4=CC(CCN(CCN5CCN6C7=C(NC[C@H]6C5)N=NC(C8=C(C=CC=C8)O)=C7)C)=NO4)=O)O)=O)C

• Molecular Weight:

  849.06

• References & Citations:

  [1]Combs AP, et al., Brm targeting compounds and associated methods of use. WO2021252666.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2755761-70-5