PROTAC SMARCA2 degrader-26

PROTAC SMARCA2 degrader-26

• CAS Number: 2760247-27-4
• UNSPSC Description: PROTAC SMARCA2 degrader-26 (compound 45) is a potent SMARCA2 PROTAC degrader. PROTAC SMARCA2 degrader-26 induces SMARCA2 and SMARCA4 degradation in VCaP cells with the percent degradation of 94% and 57% for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2 degrader-26 shows antiproliferative activity[1].
• Target Antigen: Epigenetic Reader Domain; PROTACs
• Type: Reference compound
• Related Pathways: Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-degrader-26.html
• Smiles: OC(C=CC=C1)=C1C2=CC(C(C=C3)=CC=C3NC(CC4)CCN4CC(N[C@@H](C(C)(C)C)C(N5[C@@H](C[C@H](C5)O)C(N[C@H](C6=CC=C(C7=C(N=CS7)C)C=C6)C)=O)=O)=O)=CN=N2
• Molecular Weight: 831.04
• References & Citations: [1]Chandrasekhar ABBINENI, et al. 6-substituted pyridazine compounds as smarca2 and/or smarca4 degraders. WO2022029617A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported