AChE-IN-63

CAT: 0804-HY-158261Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-158261Size:1 Each
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Description
AChE-IN-63 (Compound 5AD) is a selective inhibitor of hAChE (IC50=0.103 μM) . AChE-IN-63 also inhibits hBChE and hBACE-1 (IC50= 10 μM (hBChE) ; 1.342 μM (hBACE-1) ) . AChE-IN-63 inhibits Aβ aggregation, preventing the formation and deposition of Aβ1-42. AChE-IN-63 can effectively penetrate the blood-brain barrier and is orally effective. It is primarily used in Alzheimer's disease research[1].
CAS Number
[876685-78-8]
UNSPSC
12352005
Target
Amyloid-β; Beta-secretase; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-63.html
Solubility
10 mM in DMSO
Smiles
C1(C2=NN=C(O2)CN3CCN(CC3)C4=CC=CC=N4)=CC=CC=C1
Molecular Formula
C18H19N5O
Molecular Weight
321.38
References & Citations
[1]Singh A, et al. Structure-Guided Design, Synthesis, and Biological Evaluation of Peripheral Anionic Site Selective and Brain Permeable Novel Oxadiazole-Piperazine Conjugates against Alzheimer's Disease with Antioxidant Potential. ACS Omega. 2024 Apr 11;9 (16) :18169-18182.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

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