AChE-IN-63

• Target :

  Beta Amyloid|||Beta-Secretase|||Cholinesterase (ChE)

• Related Pathways :

  Neuroscience

• Bioactivity :

  AChE-IN-63 (Compound 5AD) serves as a selective inhibitor of hAChE, exhibiting an IC 50 value of 0.103 ?M. Moreover, it inhibits hBChE and hBACE-1 with IC 50 values of 10 ?M and 1.342 ?M, respectively. AChE-IN-63 is effective in inhibiting A? aggregation and preventing the formation and deposition of A?1-42. It can effectively penetrate the blood-brain barrier and is orally bioavailable. This compound is primarily utilized in research related to Alzheimer's disease [1].

• Smiles :

  N=1N=C(OC1C=2C=CC=CC2)CN3CCN(C4=NC=CC=C4)CC3

• Molecular Formula :

  C18H19N5O

• Molecular Weight :

  321.38

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  876685-78-8