Metformin Hydrochloride

• Background:

  Metformin Hydrochloride is an antidiabetic agent which reduces blood-glucose levels as well as improves insulin sensitivity. Metformin has also been shown to inhibit hepatic gluconeogenesis via activation of LKB1-AMPK (AMP-activated protein kinase) pathway. The activation of this pathway has also been seen to have an antiproliferative and pro-apoptotic effect in cancer cells. Lastly, Metformin is believed to induce autophagy through inhibition of the mTORC1 pathway. Neuroprotective and lowers alpha synuclein phosphorylation.

• Description:

  Autophagy inducer

• Product Name Alternative:

  N, N-Dimethylimidodicarbonimidic diamide hydrochloride

• UNSPSC:

  41116105

• Type:

  Inducer

• Source:

  Synthetic

• Field of Research:

  Cancer | Autophagy | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein

• Purity:

  ≥97%

• Weight:

  5

• Format:

  White crystalline powder.

• Solubility:

  Soluble to 100 mM in water and to 50 mM in DMSO.

• Molecular Formula:

  C4H11N5•HCl

• Molecular Weight:

  165.6

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Kirpichnikov D., et al. (2002). Ann Intern Med. 137(1): 25-33. 2. Caton P. W., et al. (2010). J Endocrino;. 205(1): 97-106. 3. Feng Y. H., et al. (2011). J Cell Mol Med. 15(4): 825-36. 4. Huang H., et al. (2013). Autophagy. 9(2): 175-95.

• CAS Number:

  1115-70-4