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Metformin Hydrochloride

CAT: 0400-SIH-395-5GSize: 5 gDry Ice: NoHazardous: No
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CAT#:0400-SIH-395-5GSize:5 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Metformin Hydrochloride is an antidiabetic agent which reduces blood-glucose levels as well as improves insulin sensitivity. Metformin has also been shown to inhibit hepatic gluconeogenesis via activation of LKB1-AMPK (AMP-activated protein kinase) pathway. The activation of this pathway has also been seen to have an antiproliferative and pro-apoptotic effect in cancer cells. Lastly, Metformin is believed to induce autophagy through inhibition of the mTORC1 pathway. Neuroprotective and lowers alpha synuclein phosphorylation.
Description
Autophagy inducer
CAS Number
1115-70-4
Product Name Alternative
N, N-Dimethylimidodicarbonimidic diamide hydrochloride
UNSPSC
41116105
Type
Inducer
Source
Synthetic
Field of Research
Cancer | Autophagy | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein
Purity
≥97%
Weight
5
Format
White crystalline powder.
Solubility
Soluble to 100 mM in water and to 50 mM in DMSO.
Molecular Formula
C4H11N5•HCl
Molecular Weight
165.6
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Kirpichnikov D., et al. (2002). Ann Intern Med. 137(1): 25-33. 2. Caton P. W., et al. (2010). J Endocrino;. 205(1): 97-106. 3. Feng Y. H., et al. (2011). J Cell Mol Med. 15(4): 825-36. 4. Huang H., et al. (2013). Autophagy. 9(2): 175-95.

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