Fingolimod (FTY720 Hydrochloride)

• Background:

  FTY720 is a potent sphingosine 1-phosphate receptors (S1P) agonist once it is phosphorylated by sphingosine kinase. This causes lymphocytes to be sequestered in lymph nodes, which also makes FTY720 an immune modulating drug for multiple sclerosis. It has been shown to stimulate neuronal gene expression, axonal growth and regeneration (3). And recently FTY720 has also been shown to reduce α-Synuclein pathology in parkinsonian GM2+/- Mice (4).

• Description:

  S1P Receptor Modulator

• Product Name Alternative:

  2-Amino-2-[2- (4-octylphenyl) ethyl]-1,3-propanediol, hydrochloride; Fingolimod

• UNSPSC:

  41116105

• Type:

  Agonist

• Source:

  Synthetic

• Field of Research:

  Cell signaling | Neuroscience | Neurodegeneration | Parkinson's Disease

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  0.025

• Format:

  White solid

• Solubility:

  Soluble to 100 mg/ml in DMSO or to 40 mg/ml in ethanol (warmed)

• Molecular Formula:

  C19H34ClNO2

• Molecular Weight:

  343.9

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Wolf A., et al. (2009) J Immunol. 183(6): 3751-60. 2. Brinkmann V., et al. (2002) J Biol Chem. 277(24): 21453-7. 3. Anastasiadou S., and Knoll B. (2016) Exp. Neurol. 279: 243-260. 4. Vidal-Martinez G., at al. (2019) Neuroscience. 411: 1-10.

• CAS Number:

  162359-56-0