Metformin (hydrochloride)

• UNSPSC Description:

  Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy[1].

• Target Antigen:

  AMPK; Autophagy; Mitophagy

• Type:

  Reference compound

• Related Pathways:

  Autophagy;Epigenetics;PI3K/Akt/mTOR

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Metabolic Disease; Cardiovascular Disease; Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Metformin-hydrochloride.html

• Solubility:

  DMSO : ≥ 1.7 mg/mL|H2O : ≥ 100 mg/mL

• Smiles:

  NC(NC(N(C)C)=N)=N.Cl

• Molecular Weight:

  165.62

• References & Citations:

  [1]Soraya H, et al. Acute treatment with metformin improves cardiac function following NSC 37745 induced myocardial infarction in rats. Pharmacol Rep. 2012;64(6):1476-84.|[2]Xue J, et al. Metformin inhibits growth of eutopic stromal cells from adenomyotic endometrium via AMPK activation and subsequent inhibition of AKT phosphorylation: a possible role in the treatment of adenomyosis. Reproduction. 2013 Aug 21;146(4):397-406.|[3]Otto M, et al. Metformin inhibits glycogen synthesis and gluconeogenesis in cultured rat hepatocytes. Diabetes Obes Metab. 2003 May;5(3):189-94.|[4]Avci CB, et al. Therapeutic potential of an anti-diabetic drug, metformin: alteration of miRNA expression in prostate cancer cells. 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• Shipping Conditions:

  Room Temperature

• Clinical Information:

  Launched

• CAS Number:

  1115-70-4