Myriocin (ISP-1)

• Background:

  Myriocin, or ISP-1, is an atypical amino acid and an antibiotic. It is a very potent inhibitor of serine palmitoyltransferase, the first step in sphingosine biosynthesis (1). It was shown to inhibit the proliferation of an IL-2-dependent mouse cytotoxic T cell line. It also possesses immunosuppressant activity (2).

• Description:

  Palmitoyltransferase inhibitor

• Product Name Alternative:

  (2S,3R,4R,6E) -2-Amino-3,4-dihydroxy-2- (hydroxymethyl) -14-oxo-6-icosenoic acid

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Apoptosis

• Purity:

  >98%

• Weight:

  0.005

• Format:

  Off-White Solid

• Solubility:

  Soluble in 2 mg/ml of methanol, DMSO (25 mg/ml; heat briefly in boiling water bath) or in dilute base (5 mg/ml; 50 mM NaOH)

• Molecular Formula:

  C21H39NO6

• Molecular Weight:

  401.54

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Hidari K.I.P.J., et al. (1996) J Biol Chem. 271: 14636-14641. 2. Miyake Y., Kozutsumi Y., Nakamura S., Fujita T. and Kawasaki T. (1995) Biochem Piophys Res Commun. 211(2): 396-403.

• CAS Number:

  35891-70-4