Spautin-1

• Background:

  Spautin-1 inhibits the deubiquitination activity of USP10 and USP13, two ubiquitin-specific peptidases. This results in the degradation of class III PI3 kinase complexes. Because this group of kinases regulates autophagy, Spautin-1 in turn inhibits autophagy.

• Description:

  Autophagy inhibitor

• Product Name Alternative:

  6-Fluoro-N-[ (4-fluorophenyl) methyl]-4-quinazolinamine

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Autophagy

• Purity:

  ≥98% (TLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  White to beige powder.

• Solubility:

  May be dissolved in DMSO (50mg/mL); or ethanol (15mg/mL, warm)

• Molecular Formula:

  C15H11F2N3

• Molecular Weight:

  271.26

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Liu J., et al. (2011) Cell. 147(1): 223-34.

• CAS Number:

  1262888-28-7